It is clear in this passage that Jesus' brothers are mocking Him, and I like how one commentator pointed out another translation of His brothers' taunts to make it even more obvious:
You can’t be famous when you hide like this! If you’re so great, prove it to the world! (The Living Bible)
The whole situation brought a few things to my mind:
1. If someone pushes me to do what I don't believe The Lord wants me to do, how do I respond? Am I willing to wait for God's direction?
2. If someone pushes me to do thing that the Lord hasn't given me the "okay" on His timing, how do I respond? Am I willing to wait for God's timing?
As Gill in his Exposition of the Entire Bible says:
Neither are your ways my ways, saith the Lord; the ways which God prescribes and directs men to walk in are different from theirs; his are holy, theirs unholy; his are plain, theirs crooked; his are ways of light, theirs ways of darkness; his are pleasant, theirs not so, at least in the issue; his lead to life, theirs to death; and therefore there is good reason why they should leave their evil ways, and walk in his.
Lord, help me to seek Your way and wait patiently for Your timing.